How to reverse the aging process with young human blood. (GDF11 ? and CREB ?)

young blood reverse aging process GDF11Reversing the aging process with young blood is an idea which I’ve had in my head as far as high school at George Washington Senior High School (1995 – 1998) and Clarinda Academy (Nov. 1995 – Nov. 1996).

I recently had the distinct pleasure of reading about the same idea in the online edition of the British newspaper, The Guardian.

Before I proceed further I want to note here that, according reporter Mark Sweney, the online edition of The Guardian became the world’s second (2nd) most popular English-language online newspaper in the world as of October, 2014.

Moreover, the online newspaper exceeded the traffic figures of the online version of The New York Times. The only English-language with more online visitors is the Daily Mail’s Mail Online (also British).

Apparently the only other online newspapers with more traffic are from China: (#1) Xinhua News Agency, (#2 ) People’s Daily Online and (#3) China Daily Sites.

First article published at The Guardian (2014)

The Guardian published an article titled, Infusions of young blood may reverse effects of ageing, studies suggest, on May 5th, 2014, by Ian Sample – science correspondent.

The article indicated that researchers in the United States were working on reversing the aging process in humans, and the harmful effects that it has on organs such as, though not limited to:

1) brain

2) heart

3) muscles

4) other organs

I’m hopeful that skin, the human body’s largest organ, is included in “other organs” because humans with the physical ability to live to age 200 (for example only) would not necessarily (or likely) want to look like they were 200 years old.

The article goes on to indicate that by giving old mice the blood of young mice that the following was subsequently observed:

a) reverse in age-related decline of memory

b) reverse in age-related decline of learning

c) reverse in age-related decline of brain function

d) reverse in age-related decline of muscle strength

e) reverse in age-related decline of stamina

Saul Villeda, PhD, of the University of California in San Francisco indicates that a protein called Creb (or CREB) was linked to an anti-aging effect that behaves as a chief regulator in the brain.

CREB stands for cAMP response element-binding protein. (NOTE: cAMP stands for Cyclic adenosine monophosphate)

The article goes on to state that other studies (these at Harvard University) appeared to indicate that blood from young mice rejuvenated the brain and muscle in old mice.

It should also be noted here that researchers at Harvard apparently “replicate the anti-ageing effects of young blood” with a blood protein called GDF11.  Apparently as mice grow older they naturally begin to have a lower amount of GDF11 in their blood.

GDF11 stands for Growth differentiation factor 11. (NOTE: also known as bone morphogenetic protein 11 or BMP-11)

Amy Wagers, PhD, of Harvard University, indicated that the protein GDF11 is identical in both humans and mice. Moreover, GDF11 is also existent in the bloodstream in humans.

Apparently GDF11 levels in humans shrink with age, as well. According to Wagers and her analyses infusions of GDF11 into older humans should likely produce the same reverse-aging effects.  She expects clinical trials of GDF11 in humans to begin in three (3) to five (5) years from now.

It should also be noted that in the above referenced article that Saul Villeda, PhD (University of California in San Francisco) stated, “I wish our manuscript could come with a big caption that says ‘Do not try this at home’. We need a clinical trial to see if this applies to humans, and to see if there are effects that we don’t want.”

Second article published at The Guardian (2015)

Last month (August 4th, 2015) Ian Sample – science correspondent at The Guardian published a second article regarding the use of young blood to reverse the aging process, Can we reverse the ageing process by putting young blood into older people?

In this new report we meet Tony Wyss-Coray, a professor of neurology at Stanford University. In the year 2008 he was leading a group of young researchers, including a PhD student named Saul Villeda (his name is referenced above in the first article), who were studying aging and neurodegeneration.

Professor Wyss-Coray’s students surgically conjoined older mice with younger mice. As the old mice received young blood they experienced a surge in brain cell growth in the hippocampus.

Furthermore, Professor Wyss-Coray and PhD student Villeda discovered that the old blood (from the older mice) had the opposite effect on young mice.  The young mice experienced a decline in brain cell growth (i.e., decline in the birth of new neurons).

Lastly, it appears that clinical trials (humans participants) has begun. Professor Wyss-Coray initiated the clinical trials of young blood infusions in October of 2014.  Apparently older individuals with Alzheimer’s are receiving infusions of blood from young individuals (NOTE: what age qualifies as young?) at the Stanford School of Medicine.

Readers can also listen to Ian Sample’s (of The Guardian) second article (which is a long, long read) rather than reading it:

http://www.theguardian.com/news/audio/2015/aug/24/can-we-reverse-ageing-process-young-blood-long-read-podcast

In closing it should also be noted that in the year 1615 Andreas Libavius, a German doctor and chemist (and alchemist), put forward the idea of connecting the arteries of an old man to those of a young man. According to an account in the Textbook of Blood Banking and Transfusion Medicine (by Sally V. Rudmann) the German doctor/chemist stated, “The hot and spirituous blood of the young man will pour into the old one as if it were from a fountain of youth, and all of his weakness will be dispelled.”  However, there are evidently (?) no known surviving records of this blood transfusion having ever occurred.

6 comments

  • Also worth reading (mainly because the article links to the published studies) is the following:

    Juvenile Blood Reverses Effects Of Aging In Mice; Could Humans Also Experience Reverse Aging?
    International Business Times
    May 05, 2014
    By Kukil Bora

    Excerpt:

    The first study [http://www.nature.com/nm/journal/v20/n6/full/nm.3569.html], published Sunday in Nature Medicine, was conducted by a group of researchers from Stanford University and the University of California at San Francisco. While the other two studies [http://www.sciencemag.org/embargo?embargoed-uri=http%3A%2F%2Fwww.sciencemag.org%2Fcontent%2Fearly%2F2014%2F05%2F02%2Fscience.1251141], published in the journal Science on Sunday, came from researchers at the Harvard Stem Cell Institute.

    The other two studies [http://hsci.harvard.edu/news/functioning-aged-brains-and-muscles-mice-made-younger], led by Wagers, showed that injections of a protein called GDF11 found in humans as well as mice improves the hearts of the old mice. It also revitalizes the stem cells in the older mice, leading to the creation of new tissues.

    Read the complete article:

    http://www.ibtimes.com/juvenile-blood-reverses-effects-aging-mice-could-humans-also-experience-reverse-aging-1579957

  • Also worth reading:

    Can Something in Young Blood Give a Boost to Old Brains?
    NIH Director’s Blog
    May 13, 2014
    by Dr. Francis Collins

    Excerpt:

    Infusing blood from younger creatures into older ones in hopes of halting—or even reversing—the aging process may sound like a macabre scene straight out of “Game of Thrones.” However, several scientific studies have shown that when older animals receive blood from younger counterparts, it improves the function of stem cells throughout the body, boosting tissue regeneration and healing. What’s not been clear is whether this activity can also rejuvenate the brain’s cognitive powers.

    For the West Coast team, led by Saul Villeda of the University of California, San Francisco and Tony Wyss-Coray of Stanford University…

    Read the complete article:

    http://directorsblog.nih.gov/2014/05/13/can-something-in-young-blood-give-a-boost-to-old-brains/

  • This afternoon I was trying to find more information regarding the clinical trials (human participants) of young blood infusions which were reportedly initiated in late 2014 at Stanford School of Medicine by Professor Wyss-Coray.

    As previously cited the second article at The Guardian (by Ian Sample) states:

    … In October 2014, Wyss-Coray launched the first human trial of young blood. At Stanford School of Medicine, infusions of blood plasma from young people are being given to older people with Alzheimer’s disease. The results are expected at the end of the year. It is the greatest test yet for the medical potential of young blood.

    I could find little information regarding the cited human trials of young blood until I a found the following today which was published in the spring of 2015 by Krista Conger – science writer for the Stanford School of Medicine’s Office of Communication & Public Affairs:

    Time in a bottle?

    Life extension gets real

    Young blood This last item is one you’re unlikely to ever store in your medicine cabinet (one would hope!). But researchers including Stanford professors of neurology Thomas Rando, MD, PhD, and Tony Wyss-Coray, PhD, have shown that infusing the blood of young mice into old mice can rejuvenate muscles, activate neuron growth and improve memory and learning in the older animals. Researchers are now trying to identify the components in the blood that provide these benefits (oxytocin, the hormone that stimulates labor in pregnant women and appears to play a role in social bonding, is an intriguing contender). In the meantime, however, a clinical trial was launched in September 2014 by Alkahest (a Menlo Park-based company founded by Wyss-Coray) to test whether regular infusions of blood from donors under the age of 30 can help people recently diagnosed with Alzheimer’s stave off memory loss and reduce other disease-related symptoms.

    clinical trials GDF11 young human blood Stanford Alkahest

    Interesting!

    So it appears that these human trials of young blood are being carried out by:

    1) a company called Alkahest in California

    2) the company was founded by Professor Tony Wyss-Coray

    3) young blood must come from donors under age 30

    I am looking at their website now: Alkahest

  • Startup Alkahest inks a $50M deal for anti-aging R&D
    Fierce Biotech
    March 4, 2015
    by Damian Garde

    Excerpt:

    Alkahest, a member of Johnson & Johnson’s ($JNJ) just-launched biotech incubator, signed a $50 million agreement with Spanish giant Grifols to hit the gas on its novel approach to treating neurodegeneration.

    Under the deal, Grifols will pay $37.5 million for a 45% stake in the Redwood City, CA, startup, handing over another $12.5 million to fund research in exchange for commercial rights to some early-stage treatments. Alkahest’s pipeline stems from the work of Stanford’s Tony Wyss-Coray, who discovered that an injection of the blood of young mice can reinvigorate the brains of elderly ones, spotlighting a new approach to treating cognitive impairment.

    Read the complete article:

    http://www.fiercebiotech.com/story/startup-alkahest-inks-50m-deal-anti-aging-rd/2015-03-04

  • The image below which is purportedly an engraving from the year 1679:

    Direct person-to-person blood transfusion at the wrist. After engraving from George Abraham Mercklino Tractatio med. Curiosa de murto et occasu transfusionis sanguinis Nuremberg, 1679. Engraving

    blood transfusion at the wrist 1679 Nuremberg
    This image is located at GettyImages.com (by clicking on the image above you will be directed to the image location).

    NOTE: I cannot verify the authenticity. At any rate, it is thought provoking.

  • Video discusses:

    (1) Senescent Cells and Telemere(s)

    (2) NAD+

    (3) Stem Cells

    See also:

    https://www.leafscience.org/blog/

    Kurzgesagt Newsletter: http://eepurl.com/cRUQxz

    Patreon (so they can make more videos and you’ll get cool stuff in return): https://www.patreon.com/Kurzgesagt?ty=h

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