How to reverse the aging process with young human blood. (GDF11 ? and CREB ?)
Reversing the aging process with young blood is an idea which I’ve had in my head as far as high school at George Washington Senior High School (1995 – 1998) and Clarinda Academy (Nov. 1995 – Nov. 1996).
I recently had the distinct pleasure of reading about the same idea in the online edition of the British newspaper, The Guardian.
Before I proceed further I want to note here that, according reporter Mark Sweney, the online edition of The Guardian became the world’s second (2nd) most popular English-language online newspaper in the world as of October, 2014.
Moreover, the online newspaper exceeded the traffic figures of the online version of The New York Times. The only English-language with more online visitors is the Daily Mail’s Mail Online (also British).
Apparently the only other online newspapers with more traffic are from China: (#1) Xinhua News Agency, (#2 ) People’s Daily Online and (#3) China Daily Sites.
First article published at The Guardian (2014)
The Guardian published an article titled, Infusions of young blood may reverse effects of ageing, studies suggest, on May 5th, 2014, by Ian Sample – science correspondent.
The article indicated that researchers in the United States were working on reversing the aging process in humans, and the harmful effects that it has on organs such as, though not limited to:
4) other organs
I’m hopeful that skin, the human body’s largest organ, is included in “other organs” because humans with the physical ability to live to age 200 (for example only) would not necessarily (or likely) want to look like they were 200 years old.
The article goes on to indicate that by giving old mice the blood of young mice that the following was subsequently observed:
a) reverse in age-related decline of memory
b) reverse in age-related decline of learning
c) reverse in age-related decline of brain function
d) reverse in age-related decline of muscle strength
e) reverse in age-related decline of stamina
Saul Villeda, PhD, of the University of California in San Francisco indicates that a protein called Creb (or CREB) was linked to an anti-aging effect that behaves as a chief regulator in the brain.
CREB stands for cAMP response element-binding protein. (NOTE: cAMP stands for Cyclic adenosine monophosphate)
The article goes on to state that other studies (these at Harvard University) appeared to indicate that blood from young mice rejuvenated the brain and muscle in old mice.
It should also be noted here that researchers at Harvard apparently “replicate the anti-ageing effects of young blood” with a blood protein called GDF11. Apparently as mice grow older they naturally begin to have a lower amount of GDF11 in their blood.
GDF11 stands for Growth differentiation factor 11. (NOTE: also known as bone morphogenetic protein 11 or BMP-11)
Amy Wagers, PhD, of Harvard University, indicated that the protein GDF11 is identical in both humans and mice. Moreover, GDF11 is also existent in the bloodstream in humans.
Apparently GDF11 levels in humans shrink with age, as well. According to Wagers and her analyses infusions of GDF11 into older humans should likely produce the same reverse-aging effects. She expects clinical trials of GDF11 in humans to begin in three (3) to five (5) years from now.
It should also be noted that in the above referenced article that Saul Villeda, PhD (University of California in San Francisco) stated, “I wish our manuscript could come with a big caption that says ‘Do not try this at home’. We need a clinical trial to see if this applies to humans, and to see if there are effects that we don’t want.”
Second article published at The Guardian (2015)
Last month (August 4th, 2015) Ian Sample – science correspondent at The Guardian published a second article regarding the use of young blood to reverse the aging process, Can we reverse the ageing process by putting young blood into older people?
In this new report we meet Tony Wyss-Coray, a professor of neurology at Stanford University. In the year 2008 he was leading a group of young researchers, including a PhD student named Saul Villeda (his name is referenced above in the first article), who were studying aging and neurodegeneration.
Professor Wyss-Coray’s students surgically conjoined older mice with younger mice. As the old mice received young blood they experienced a surge in brain cell growth in the hippocampus.
Furthermore, Professor Wyss-Coray and PhD student Villeda discovered that the old blood (from the older mice) had the opposite effect on young mice. The young mice experienced a decline in brain cell growth (i.e., decline in the birth of new neurons).
Lastly, it appears that clinical trials (humans participants) has begun. Professor Wyss-Coray initiated the clinical trials of young blood infusions in October of 2014. Apparently older individuals with Alzheimer’s are receiving infusions of blood from young individuals (NOTE: what age qualifies as young?) at the Stanford School of Medicine.
Readers can also listen to Ian Sample’s (of The Guardian) second article (which is a long, long read) rather than reading it:
In closing it should also be noted that in the year 1615 Andreas Libavius, a German doctor and chemist (and alchemist), put forward the idea of connecting the arteries of an old man to those of a young man. According to an account in the Textbook of Blood Banking and Transfusion Medicine (by Sally V. Rudmann) the German doctor/chemist stated, “The hot and spirituous blood of the young man will pour into the old one as if it were from a fountain of youth, and all of his weakness will be dispelled.” However, there are evidently (?) no known surviving records of this blood transfusion having ever occurred.